PERSONAL INFORMATION
Name: Jihan Xia
Gender: Male
CONTACT INFORMATION
Email: xiajihan@126.com
EDUCATION EXPERIENCE
2005.09 – 2009.07, Northeast Agricultural University, Bachelor of Science
2009.09 – 2012.07, Chinese Academy of Agricultural Sciences, Master of Agriculture
2016.01 – 2020.02, University of Oulu, Doctor of Philosophy
WORKING EXPERIENCE
2023. till now, Chongqing Medical University, Institute of Life Science, Principal Investigator
2021.09 – 2023.09, Academy of Finland, University of Helsinki, Postdoc
2020.09 – 2021.09, University of Helsinki, Postdoc
2020.02 – 2020.09, University of Oulu, Postdoc
2012.07 - 2015.12, Chinese Academy of Agricultural Sciences, Research Assistant
RESEARCH INTERESTS
The main research interest of Jihan Xia is tumor functional genomics of obesity and metabolic diseases. We utilize molecular biology technologies to research tumor transcription factors and oncogene regulation. Our research group aims to understand the mechanism of lineage-specific transcription factors and regulatory elements driving tumorigenesis in metabolic disorders. The key transcription factors, tumor epigenomics, and tumor genetic mutation were generally analyzed to understand how oncogenes drive tumor development and progression. The main methods include ChIP-seq and CUT&RUN, DNA methylome, ATAC-seq, HiChIP, STARR-seq, CRISPR-Cas9 systems, etc. We focus on the role of pioneer factors and other transcription factors in epigenome reprogramming and cellular fate. Moreover, transcription factors play an important role in non-coding regulatory elements that affect the abnormal expression of cell type-specific oncogenes. The abnormal activity of these elements which may be as enhancers, promoters, or insulators, promotes tumor development and epigenetic reprogramming. To decipher the association between the epigenetic and clinical data, we comprehensively analyze between epigenetics of tumor cells and clinical data such as cancer risk-associated SNPs and histopathological phenotype. Our molecular mechanism research would contribute to tumor drug research and the diagnosis of tumors.
HONOUR & AWARDS
1. The BCO Discovery of the Year 2018, Biocenter, University of Oulu, Finland.
2. National Excellent International Student Scholarship, 2019, China.
3. Chongqing Youth Talents
PUBLICATIONS
1. Gao P#, Xia JH#, Sipeky C, Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SP, Zhang K, Zhu J, Lee HM, Suleman S, Giannareas N, Liu S, et al. Biology and clinical implications of the 19q13 aggressive prostate cancer susceptibility locus. Cell. 2018 Jul 26;174(3):576-589.e18. doi: 10.1016/j.cell.2018.06.003. Epub 2018 Jul 19.
2. Zhang P#, Xia JH#, Zhu J, Gao P, Tian YJ, Du M, Guo YC, Suleman S, Zhang Q, Kohli M, Tillmans LS, Thibodeau SN, French AJ, Cerhan JR, Wang LD, Wei GH, Wang L. High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing. Nat Commun. 2018 May 22;9(1):2022. doi: 10.1038/s41467-018-04451-x.
3. Xia JH#*, Wei GH*. Enhancer Dysfunction in 3D Genome and Disease. Cells. 2019 Oct 19;8(10). pii: E1281. doi: 10.3390/cells8101281.
4. Musaddeque A#; Fraser S#; Ji-Han Xia#; Yue Yang; et al; CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer, Nature Communications, 2021, 12(1): 1781-1781.
5. S Skarp#, JH Xia#, Q Zhang, M Löija, A Costantini, LW Ruddock, O Mäkitie, Exome Sequencing Reveals a Phenotype Modifying Variant in ZNF528 in Primary Osteoporosis With a COL1A2 Deletion. Journal of Bone and Mineral Research, 2020，35 (12), 2381-2392.
6. Jihan Xia, Xin L, Zhu W, Li L, Li C, Wang Y, Mu Y, Yang S, Li K. Characterization of long non-coding RNA transcriptome in high-energy diet induced nonalcoholic steatohepatitis minipigs. Sci Rep. 2016 Jul 28;6:30709. doi: 10.1038/srep30709.
7. Shulin Y#, Jihan Xia#, Yuanyuan Zhang, Jiangao Fan, Hua Wang, Jin Yuan, Zhanzhao Zhao, Qin Pan, Yulian Mu, Leilei Xin, Yaoxing Chen, Kui Li. (2015) Insulin resistance lead to the cellular damage in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs, Scientific Reports. (co-first authors)
8. Xia Jihan, Yuan J, Xin L, Zhang Y, Kong S, et al. (2014) Transcriptome analysis on the inflammatory cell infiltration of nonalcoholic steatohepatitis in bama minipigs induced by a long-term high-fat, high-sucrose diet. PLoS One 9: e113724.
9. Xia Jihan, Hu B, Mu Y, Xin L, Yang S, et al. (2014) Molecular cloning and characterization of the promoter region of the porcine apolipoprotein E gene. Mol Biol Rep 41: 3211-3217. (IF=2.0)
10. Xia Jihan, Xin L, Zhang Y, Kong S, Shu L, et al. Global transcriptomic profiling on the cardiac hypertrophy and fatty heart in Bama minipigs induced by a long-term high-fat, high-sucrose diet, 2015, PLoS One, 10(7): e0132420.
11. Xia Jihan, Liu Z, Xin L, Wang Z, Qian L, et al. (2014) Molecular characterization of swine leukocyte antigen class I genes by sequence-based and PCR-SSP method in Guizhou minipigs. Mol Biol Rep.
12. XIA Jihan, Wang, C.Q., Ruan, J.X., Yang, S. L., Li, K. Construction of 11β-HSD1 Eukaryotic Over Expression Vector and its Expression in Hepa1-6 [J] China Animal Husbandry And Veterinary Medicine, 2012, 39(12):176-180.
13. Zizhanliu#, Jihan Xia#, Leilei Xin, Zaigui Wang, Lin Qian, Shuguang Wu, Shulin Yang, Kui Li. Swine leukocyte antigen class II genes (SLA-DRA, SLA-DRB1, SLA-DQA, SLA-DQB1) polymorphism and genotyping in Guizhou minipigs. (Genetics and Molecular Research)
14. Xia JH, Wei GH. Oncogenic regulatory circuits driven by 19q13 rs11672691 underlie prostate cancer aggressiveness. Mol Cell Oncol.
