PERSONAL INFORMATION
Name: Hai-Xin Yuan
Gender: Male
Title: Dr.
Position: Professor
CONTACT INFORMATION
Email: yuanhaixin@cqmu.edu.cn
Address: No. 1 Yixueyuan Road, Yuzhong District,
Chongqing 400016, China
Phone: +86-23-68481352
EDUCATION EXPERIENCE
1998-2002 Undergraduate student in the School of Life Sciences, University of Science and Technology of China (USTC), Hefei, China, B.S.
2002-2008 Graduate student in the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China, Ph.D.
(Biochemistry and Molecular Biology, Mentor: Zhengjun Chen, Ph.D.)
WORKING EXPERIENCE
2009/09-2014/08
Postdoctoral fellow in Moores Cancer Center, University of California at San Diego, USA (Mentor: Kun-Liang Guan, Ph.D.)
2014/11-2019/11
Associate Professor, Institutes of Biomedical Sciences, Fudan University
2016/12-2019/12
Associate Professor, Shanghai Fifth People’s Hospital, Fudan University
2019/12-2021/12
Professor, Institutes of Biomedical Sciences, Fudan University
2020/01-2021/12
Principle Investigator, Shanghai Fifth People’s Hospital, Fudan University
2022/01-present
Professor, Institute of Life Sciences, Chongqing Medical University
RESEARCH INTERESTS
Regulatory Mechanisms of Cell Metabolism and Cell Death
HONOUR & AWARDS
1. Development Fund for Shanghai Talents
2. Distinguished Professor of Shanghai Universities (Oriental Scholar)
3. Supporting Fund for Innovation and Entrepreneurship by Chongqing Returned Oversea Scholars
SELECTED PUBLICATIONS
1. Liu JP#, Cen SY#, Xue Z, Wang TX, Gao Y, Zheng J, Zhang C, Hu J, Nie S, Xiong Y, Guan KL, Yuan HX*. A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. ACS Chem Biol. 2022, 17(12):3389-3406.
2. Sun SJ#, Ai Y#, Duan KL, Zhang JY, Zhang C, Sun YP, Xiong Y, Guan KL, and Yuan HX*. TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression. Oncogene 2022, 41:5385-5396.
3. Wang TX#, Duan KL#, Huang ZX, Xue ZA, Liang JY, Dang Y, Zhang A, Xiong Y, Ding C*, Guan KL and Yuan HX*. Tanshinone functions as a coenzyme that confers gain-of-function of NQO1 to suppress ferroptosis. Life Sci Alliance 2022, 6:e202201667.
4. Hu M#, Bao R#, Lin M#, Han XR, Ai YJ, Gao Y, Guan KL, Xiong Y, and Yuan HX*. ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3. Oncogene 2022, 41:4547-4559.
5. Liu P#, Sun SJ#, Ai Y#, Feng X, Zheng YM, Gao Y, Zhang JY, Zhang L, Sun YP, Xiong Y, Lin M*, and Yuan HX*. Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance. Cell Death Dis. 2022, 13:205. (*co-corresponding)
6. Bao R, Meng Y, Zhang H, Yang C, Li W, Zhang C, Zhang J, Sun R, Li Z, Jiang W, Zhang C, Zhang C*, Yuan HX*, and Dang Y*. Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. Cell Death Dis. 2021, 12:972. (*co-corresponding)
7. Liu P#, Liu JP#, Sun SJ#, Gao Y, Ai Y, Chen X, Sun Y, Zhou M, Liu Y, Xiong Y, and Yuan HX. CBFB-MYH11 fusion sequesters RUNX1 in cytoplasm to prevent DNMT3A recruitment to target genes in AML. Front Cell Dev Biol. 2021, 9:675424.
8. Li X, Wang TX, Huang X, Li Y, Sun T, Zang S, Guan KL, Xiong Y, Liu J*, and Yuan HX*. Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver Int. 2020, 40:1378-1394. (*co-corresponding)
9. Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL, and Yuan HX. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis. 2019, 10:755.
10. Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, and Yuan HX. ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). Biochem J. 2019, 476:2239-2254.
11. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, and Yuan HX. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018, 9:508.
12. Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH*, Yuan HX*, and Xiong Y*. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene 2018, 37:1637-1653. (*co-corresponding)
13. Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, and Yuan HX. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017, 284: 3619-3636.
14. Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y*, Yuan HX*, and Guan KL*. Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ. Cancer Res. 2017, 77: 2413-2423. (*co-corresponding)
15. Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng ZP, Sun YP, Yu Y, Xiong Y*, Yuan HX*, and Guan KL*. Thromboxane A2 Activates YAP/TAZ to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016, 291: 18947-18958. (*co-corresponding)
16. Yuan HX* and Guan KL*. Structural insights of mTOR complex 1. Cell Res. 2016, 26: 267-268. (*co-corresponding)
17. Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, and Guan KL. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Gene Dev. 2015, 29: 2362-2376.
18. Yuan HX and Guan KL. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015, 5: 1127-1129.
19. Yuan HX, Russell RC, and Guan KL. Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Autophagy 2013, 9: 1983-1995.
20. Yuan HX, Xiong Y, and Guan KL. Nutrient sensing, metabolism, and cell growth control. Mol Cell. 2013, 49: 379-387.
21. Yuan H#, Zhang H#, Wu X, Zhang Z, Du D, Zhou W, Zhou S, Brakebusch C, and Chen Z. Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice. Hepatology 2009, 49: 240-249. (#co-first)
22. Yuan H, Zhang L, Liu A, Zhou H, Wang Y, Zhang H, Wang G, Zeng R, Zhang Y, and Chen Z. Proteomic profiling of regionalized proteins in rat epididymis indicates consistency between specialized distribution and protein functions. J. Proteome Res. 2006, 5: 299-307.
