PERSONAL INFORMATION
Name：Lei Du
Gender：Male
CONTACT INFORMATION
Email：alien18@163.com
EDUCATION EXPERIENCE
2001.9-2005.6：B.Eng. Physics, Department of Physics, East China Normal University
2005.9-2008.6：M.Sc. MRI Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University
2008.9-2011.12：Ph.D. MRI Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University
WORKING EXPERIENCE
2022.12-present, Distinguished Professor, Department of Medical Informatics, Chongqing Medical University
2016.03-present, Newton International Fellow, The Royal Society
2018.06-2022.09, Research scientist, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, US - Supervisor: Melissa Delbello
2015.12-2018.03, Research scientist, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK - Supervisor: Andrea Mechelli
2012.06-2015.12, Post-Doctoral Fellow, Huaxi MR Research Center, West China Hospital, Sichuan University, China: Supervisor - Qiyong Gong
RESEARCH INTERESTS
My research interests center on application of artificial intelligence in medical imaging and application of multiple MRI techniques in exploring biological and cognitive underpinnings of psychiatric and neurological disorders such as bipolar disorder, depression, schizophrenia, PTSD, and ADHD. The main innovation work focuses on exploring the functional and structural differences of the brains of patients with brain diseases from the perspective of complex brain networks. More recently, my current research focuses on the supervised machine learning techniques (as well as deep learning technically) to improve diagnostic and prognostic assessment in psychiatry, which could greatly increase the likelihood that the results can be translated into a tool that is useful in a real-world clinical setting. I had published a total of 105 articles, these articles have been cited more than 2,500 times in the recent years, and the h-index of the applicant is 27 (by Google Scholar).
HONOR & AWARDS
1. The First Prize of Huaxia Medical Science and Technology Award, 2018
2. The First Prize of Chinese Medical Science and Technology Award, 2017
3. Newton international fellow, Royal Society, 2016
4. Young Investigator Award, Overseas Chinese Society for Magnetic Resonance in Medicine (OCSMRM), Toronto, June 2015.
PUBLICATIONS
1. Du Lei, Kun Qin, Wenbin Li, Ziyu Zhu, Maxwell J Tallman, L Rodrigo Patino, David E Fleck, Veronica Aghera, Qiyong Gong, John A Sweeney, Melissa P DelBello, Robert K McNamara, Regional microstructural differences in ADHD youth with and without a family history of bipolar I disorder,Journal of Affective Disorders, 2023 334, 238-245.
2. Du Lei#*, Kaiming Li, Lingjiang Li, Fuqin Chen, Xiaoqi Huang, Su Lui, Jing Li, Feng Bi, Qiyong Gong*, Disrupted Functional Brain Connectome in Patients with Posttraumatic Stress Disorder, Radiology, 2015, 276:818-827.
3. Wenbin Li#, Du Lei#, Maxwell J. Tallman, Yuan Ai, Jeffrey A. Welge, Thomas J. Blom, David E. Fleck, Christina C. Klein, L. Rodrigo Patino, Jeffrey R. Strawn, Qiyong Gong*, John A. Sweeney, Caleb M. Adler,Melissa P. DelBello. Pretreatment alterations and acute medication treatment effects on task-related functional brain connectivity in youth with bipolar disorder: A randomized clinical trial comparing lithium and quetiapine outcomes. Journal of the American Academy of Child and Adolescent Psychiatry, 2022.
4. Du Lei#*, Kun Qin#, Wenbin Li, Walter H. L. Pinaya, Maxwell J. Tallman, L. Rodrigo Patino, Jeffrey R. Strawn, David Fleck, Christina C. Klein, Su Lui, Qiyong Gong, Caleb M. Adler, Andrea Mechelli, John A. Sweeney, Melissa P. DelBello. Brain morphometric features predict medication response in youth with bipolar disorder: a prospective randomized clinical trial. Psychological Medicine, 2022, in press.
5. Du Lei, Walter H. L. Pinaya, Therese van Amelsvoort, Machteld Marcelis, Gary Donohoe, David O. Mothersill, Aiden Corvin, Michael Gill, Sandra Vieira, Xiaoqi Huang, Su Lui, Cristina Scarpazza, Jonathan Young, Celso Arango, Edward Bullmore, Qiyong Gong, Philip McGuire, Andrea Mechelli. Detecting schizophrenia at the level of the individual: relative diagnostic value of regional activation, connectome-wide functional connectivity and graph-based networks. Psychological Medicine, 2020, Aug;50(11):1852-1861.
6. Kun Qin#, Du Lei#, Walter H. L. Pinaya, Nanfang Pan, Wenbin Li, Ziyu Zhu, John A. Sweeney, Andrea Mechelli, Qiyong Gong. Using graph convolutional network to characterize individuals with major depressive disorder across multiple imaging sites. EBioMedicine, 2022, in press.
7. Du Lei#, Kun Qin#, Walter H. L. Pinaya, Jonathan Young, Therese van Amelsvoort,Machteld Marcelis, Gary Donohoe, David O. Mothersill, Aiden Corvin, Sandra Vieira,Su Lui, Cristina Scarpazza, Celso Arango, Ed Bullmore, Gong Qiyong, Philip McGuire, Andrea Mechelli. Graph convolutional networks reveal network-level functional dysconnectivity in schizophrenia. Schizophrenia Bulletin, 2022, 48(4): 881-892
8. Du Lei#*, Wenbin Li, Kun Qin, Yuan Ai, Maxwell J Tallman, L Rodrigo Patino, Jeffrey A Welge, Thomas J Blom, Christina C Klein, David E Fleck, Qiyong Gong, Caleb M Adler, Jeffrey R Strawn, John A Sweeney, Melissa P DelBello. Effects of short-term quetiapine and lithium therapy for acute manic or mixed episodes on the limbic system and emotion regulation circuitry in youth with bipolar disorder. Neuropsychopharmacology, in press.
9. Du Lei#*, Wenbin Li#, Maxwell J. Tallman, Stephen M. Strakowski, Melissa P. DelBello, L. Rodrigo Patino, David E. Fleck, Su Lui, Qiyong Gong, Prof. John A. Sweeney, PhD, Prof. Jeffrey R. Strawn, Fabiano G. Nery, Jeffrey A. Dr. Welge, Emily Rummelhoff, Caleb M. Adler.Changes in the structural connectome over the course of a nonrandomized clinical trial for acute mania. Neuropsychopharmacology, 47, pages1961–1968 (2022).2022.
10. Du Lei#, Xueling Suo#, Kun Qin, Walter Pinaya, Yuan Ai, Wenbin Li, Weihong Kuang, Su Lui, Graham J. Kemp, John Sweeney, Qiyong Gong. Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia. Translational Psychiatry, (2022) 12:189.
