PERSONAL INFORMATION
Name: Deng Chun
Gender: Female
Title: Professor, DIRECTOR, YONGCHUAN
HOSPITAL OF CONGQING MEDICAL UNIVERSITY
Position:Chief of Pediatrics
CONTACT INFORMATION
Email: erkedengchun@126.com
EDUCATION EXPERIENCE
1991 Graduated from Chongqing Medical University, Pediatrics, Bachelor
2004 Chongqing Medical University, Pediatrics, PhD
2008 Okayama Medical Center in Japan, NICU (Neonatal Intensive Care Unit), Visiting Scholar
2013 Harvard University, Beth Israel Medical Center Neonatal Center, Visiting Scholar
WORKING EXPERIENCE
2019.10 till now Yongchuan Hospital of Chongqing Medical University, Chief Physician
2010.07-2019.10 Children's Hospital of Chongqing Medical University, Chief Physician
2002.07-2010.06 Children's Hospital of Chongqing Medical University, Associate Chief Physician
1996.07-2002.06 Children's Hospital of Chongqing Medical University, Attending Physician
1991.07-1996.06 Children's Hospital of Chongqing Medical University, Resident Physician
RESEARCH INTERESTS
The primary focus of Prof. Deng revolves around the intricacies of neonatal care, particularly the resuscitation and treatment of premature and extremely premature infants. Her intensive research endeavors aim to unearth the underlying mechanisms of bronchopulmonary dysplasia in extremely premature infants. Addressing this significant challenge, Prof. Deng and her dedicated research team have delved deep into clinical and experimental studies, securing prominent grants in the process. She has notably been the lead investigator for two projects funded by the National Natural Science Foundation(30770950;81270058) and one by the Chongqing Science Commission(CSTC, 2009BB6072), while also contributing to four additional projects under the National Natural Science Foundation.
Prof. Deng has published more than 60 papers, 15 of total have been recognized in the Science Citation Index (SCI) and 22 in the Chinese Science Citation Database (CSCD). 36 master's students have successfully graduated under the guidance of Prof. Deng.
Clinically, Prof. Deng excels in the realms of neonatal care. She is an expert in pediatric respiratory system diseases, chronic coughs, digestive system issues, and other ill pediatric diseases. Prof. Deng has comprehensive experience and dedication to pediatric healthcare.
HONOUR & AWARDS
2009: Outstanding worker of Children Hospital of Chongqing Medical University
2010: Model Teacher of Chongqing Medical University
PUBLICATIONS
1.Tian B, Zhang Y, Deng C, Guo C. Efficacy of Probiotic Consortium
Transplantation on Experimental Necrotizing Enterocolitis. J Surg Res. 2022
Nov;279:598-610. doi: 10.1016/j.jss.2022.05.030. Epub 2022 Aug 1. PMID:
35926310.
2. Mo D, Deng C, Chen B, Ding X, Deng Q, Guo H, Chen G, Ye C, Guo C. The
severity of NEC is ameliorated by prostaglandin E2 through regulating intestinal
microcirculation. Sci Rep. 2023 Aug 17;13(1):13395. doi:
10.1038/s41598-023-39251-x. PMID: 37591866; PMCID: PMC10435505.
3.Luo Y, Mo D, Guo H, Ye C, Chen B, Zhu H, Deng C, Deng Q, Guo C, Qiu L. NF-κB
inactivation attenuates the M1 macrophage polarization in experimental
necrotizing enterocolitis by glutaredoxin-1 deficiency. Cell Biol Int. 2022
Nov;46(11):1886-1899. doi: 10.1002/cbin.11861. Epub 2022 Jul 23. Erratum in:
Cell Biol Int. 2023 Mar;47(3):679. PMID: 35870170.
4.Yu B, Li X, Wan Q, Han W, Deng C, Guo C. High-Mobility Group Box-1 Protein
Disrupts Alveolar Elastogenesis of Hyperoxia-Injured Newborn Lungs. J Interferon
Cytokine Res. 2016 Mar;36(3):159-68. doi: 10.1089/jir.2015.0080. Epub 2016 Jan
27. PMID: 26982166.
5. Zeng S, Li X, Deng C, Li L, Guo C. Evaluation of parenteral nutrition-
associated liver disease in surgical infants for necrotizing enterocolitis.
Medicine (Baltimore). 2020 Jan;99(2):e18539. doi: 10.1097/MD.0000000000018539.
PMID: 31914027; PMCID: PMC6959898.
6.Zhang X, Tian B, Deng Q, Cao J, Ding X, Liu Q, Zhang Y, Ye C, Deng C, Qiu L,
Guo C. Nicotinamide riboside relieves the severity of experimental necrotizing
enterocolitis by regulating endothelial function via eNOS deacetylation. Free
Radic Biol Med. 2022 May 1;184:218-229. doi:
10.1016/j.freeradbiomed.2022.04.008. Epub 2022 Apr 14. PMID: 35430341.
7.Li C, Li X, Deng C, Guo C. Circulating Fibrocytes Are Increased in Neonates
with Bronchopulmonary Dysplasia. PLoS One. 2016 Jun 16;11(6):e0157181. doi:
10.1371/journal.pone.0157181. PMID: 27309347; PMCID: PMC4911073.
8.Zhang H, Chen J, Wang Y, Deng C, Li L, Guo C. Predictive factors and clinical
practice profile for strictures post-necrotising enterocolitis. Medicine
(Baltimore). 2017 Mar;96(10):e6273. doi: 10.1097/MD.0000000000006273. PMID:
28272242; PMCID: PMC5348190.
9. Deng S, Zhang H, Han W, Guo C, Deng C. Transforming Growth Factor-β-
Neutralizing Antibodies Improve Alveolarization in the Oxygen-Exposed Newborn Mouse Lung. J Interferon Cytokine Res. 2019 Feb;39(2):106-116. doi:
10.1089/jir.2018.0080. Epub 2019 Jan 18. PMID: 30657417.
10.Wang H, Wang Y, Deng C, Li L, Guo C. Prediction of intestinal failure from
necrotizing enterocolitis following surgery: A multicenter retrospective review.
Medicine (Baltimore). 2019 May;98(19):e15568. doi: 10.1097/MD.0000000000015568.
PMID: 31083227; PMCID: PMC6531265.
11.Han W, Li X, Zhang H, Yu B, Guo C, Deng C. Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia. Int J Biochem Cell
Biol. 2017 Nov;92:173-182. doi: 10.1016/j.biocel.2017.08.004. Epub 2017 Aug 10.
PMID: 28802561.
12.Wang J, Bao L, Yu B, Liu Z, Han W, Deng C, Guo C. Interleukin-1β Promotes
Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β
Activation. Cell Physiol Biochem. 2015;36(6):2198-216. doi: 10.1159/000430185.
Epub 2015 Jul 24. PMID: 26279426.
13. Li X, Li L, Wang Y, Deng C, Guo C. Postoperative characteristics of infants
who developed necrotizing enterocolitis with different postnatal ages. Medicine
(Baltimore). 2017 Aug;96(32):e7774. doi: 10.1097/MD.0000000000007774. PMID:
28796074; PMCID: PMC5556240.
14.Xie X, Guo S, Deng C, Guo C. Postoperative outcomes based on crystalloid
administration in pediatric patients with necrotizing enterocolitis undergoing
laparotomy. Medicine (Baltimore). 2020 Oct 2;99(40):e21987. doi:
10.1097/MD.0000000000021987. PMID: 33019391; PMCID: PMC7535651.
15.You Y, Guo C, Zhang H, Deng S, Tang J, Xu L, Deng C, Gong F. Effect of
Intranasal Instillation of Lipopolysaccharide on Lung Development and Its
Related Mechanism in Newborn Mice. J Interferon Cytokine Res. 2019
Nov;39(11):684-693. doi: 10.1089/jir.2019.0006. Epub 2019 Jul 3. PMID: 31268385;
PMCID: PMC6820870.
16. Liu Y, Qingjuan S, Gao Z, Deng C, Wang Y, Guo C. Circulating fibrocytes are
involved in inflammation and leukocyte trafficking in neonates with necrotizing
enterocolitis. Medicine (Baltimore). 2017 Jun;96(26):e7400. doi:
10.1097/MD.0000000000007400. PMID: 28658176; PMCID: PMC5500098.
17.Deng C, Wang J, Zou Y, Zhao Q, Feng J, Fu Z, Guo C. Characterization of
fibroblasts recruited from bone marrow-derived precursor in neonatal
bronchopulmonary dysplasia mice. J Appl Physiol (1985). 2011 Jul;111(1):285-94.
doi: 10.1152/japplphysiol.00201.2010. Epub 2011 Jan 13. PMID: 21233340.
18. Pu CL, Guo CB, Jin XQ, Deng C, Zhang MM, Li YC, Kang Q. [Retrospective
analysis of maternal and infant birth features of hepatoblastoma patients].
Zhonghua Gan Zang Bing Za Zhi. 2009 Jun;17(6):459-61. Chinese. PMID: 19567028.
19. Deng C, Li X, Zou Y, Wang J, Wang J, Namba F, Hiroyuki Y, Yu J, Yamauchi Y,
Guo C. Risk factors and pathogen profile of ventilator-associated pneumonia in a
neonatal intensive care unit in China. Pediatr Int. 2011 Jun;53(3):332-7. doi:
10.1111/j.1442-200X.2011.03382.x. PMID: 21496177.
20. Feng J, Deng C, Yu JL, Guo CB, Zhao QQ. [Expression of high mobility group
protein-B1 in mice with hyperoxia-induced bronchopulmonary dysplasia]. Zhongguo Dang Dai Er Ke Za Zhi. 2010 Mar;12(3):219-23. Chinese. PMID: 20350435.
21.Liu X, Li K, Zhang F, Zhang Y, Deng C, Guo C. Ablation of glutaredoxin 1
promotes pulmonary angiogenesis and alveolar formation in hyperoxia-injured
lungs by modifying HIF-1α stability and inhibiting the NF-κB pathway. Biochem
Biophys Res Commun. 2020 Apr 30;525(2):528-535. doi: 10.1016/j.bbrc.2020.02.129.
Epub 2020 Feb 26. PMID: 32113683.
22. Guo CB, Wang S, Deng C, Zhang DL, Wang FL, Jin XQ. Relationship between
matrix metalloproteinase 2 and lung cancer progression. Mol Diagn Ther.
2007;11(3):183-92. doi: 10.1007/BF03256240. PMID: 17570740.
23. Jin X, Qiu L, Zhang D, Zhang M, Wang Z, Guo Z, Deng C, Guo C.
Chemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs
via NF-kappaB and mitochondrial cytochrome c cascade. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4596-607. doi: 10.1111/j.1582-4934.2008.00601.x. PMID: 19067767;PMCID: PMC4515074.
24. Deng C, Guo CB, Xu YH, Deng B, Yu JL. Three mutations analysis of
glucose-6-phosphate dehydrogenase deficiency in neonates in South-west China.
Pediatr Int. 2007 Aug;49(4):463-7. doi: 10.1111/j.1442-200X.2007.02398.x. PMID:
17587269.
25. Jin X, Wang Z, Qiu L, Zhang D, Guo Z, Gao Z, Deng C, Wang F, Wang S, Guo C.
Potential biomarkers involving IKK/RelA signal in early stage non-small cell
lung cancer. Cancer Sci. 2008 Mar;99(3):582-9. doi:10.1111/j.1349-7006.2007.00713.x. Epub 2008 Jan 21. PMID: 18215193.
26. Han W, Guo C, Liu Q, Yu B, Liu Z, Yang J, Deng C. Aberrant elastin remodeling
in the lungs of O₂-exposed newborn mice; primarily results from perturbed
interaction between integrins and elastin. Cell Tissue Res. 2015
Feb;359(2):589-603. doi: 10.1007/s00441-014-2035-1. Epub 2014 Nov 27. PMID:
25428696.
27. Gao Z, Shang Q, Liu Z, Deng C, Guo C. Mitochondrial ATF2 translocation
contributes to apoptosis induction and BRAF inhibitor resistance in melanoma
through the interaction of Bim with VDAC1. Oncotarget. 2015 Nov
3;6(34):36338-53. doi: 10.18632/oncotarget.5537. PMID: 26462148; PMCID:
PMC4742181.
28. Zhang D, Jin X, Wang F, Wang S, Deng C, Gao Z, Guo C. Combined prognostic
value of both RelA and IkappaB-alpha expression in human non-small cell lung
cancer. Ann Surg Oncol. 2007 Dec;14(12):3581-92. doi: 10.1245/s10434-007-9560-z.
Epub 2007 Sep 27. PMID: 17899287.
29. Qiu L, Deng C, Fu Z, Guo C. The role of transforming growth factors beta1 and
beta3 in pre- and post-natal pulmonary surfactant development. Cell Biol Int.
2011 Mar;35(3):287-92. doi: 10.1042/CBI20090486. PMID: 20973761.
30. Liu FJ, Deng C, Guo CB, Fu Z. [Effect of hyperoxia and TGF-β1 on epithelial-
mesenchymal transition of type II alveolar epithelial cells]. Xi Bao Yu Fen Zi
Mian Yi Xue Za Zhi. 2012 May;28(5):474-7. Chinese. PMID: 22558985.
31. Deng C, Guo CB, Yu JL, Wu SX, Tan Y. [Expression of Ref-1 and FAP-1 mRNA in hypoxic-ischemic injury in neonatal rat]. Zhonghua Er Ke Za Zhi. 2003
Apr;41(4):297-9. Chinese. PMID: 1475454
