PERSONAL INFORMATION
Name: Xiaolin Tu
Gender: Male
Title: Doctor, Professor
Position: Director of the Laboratory of Skeletal Development and Regeneration, Mentor of doctoral and master’s program; Leading scientist in Chongqing's Chief Expert Studio; Chongqing Academic and Technological Leader (Orthopedics); Member or executive member of the 5 national academic societies.
CONTACT INFORMATION
Email: xtu@cqmu.edu.cn
Address: 1 Yi-Xue-Yuan Road, Yuzhong District, Chongqing 400016, China
Phone: +86-18523820685
EDUCATION EXPERIENCE
1984.9-1988.6 Bachelor in Microbiology, Jiangxi University (Nanchang University)
1988.9-1991.6 Master degree in Veterinary Microbiology and Immunology, Nanjing Agricultural University
1996.10-1999.9 PhD in Bioresource Production Science, Ehime University, Japan
WORKING EXPERIENCE
1991.7-1996.9 Teaching Assistant, Lecturer, Associate Professor in the Department of Aquaculture, Shanghai Fisheries University (currently, Shanghai Ocean University), resigned in 2004.02
1999.10-2001.8 Postdoctoral researcher, Proteomics and Immunology, University of Victoria, Canada
2001.9-2003.12 Postdocoral researcher in Clinical Immunology and Allergy, University of California-Los Angeles School of Medicine, USA
2004.1-2009.10 Research Associate in the Division of Bone Mineral Disease, Washington University in St. Louis School of Medicine, USA
2009.11-2014.10 Assistant Professor in the Department of Anatomy and Cell Biology, Indiana University School of Medicine, USA
2014.11-current Professor, Institute of Life Sciences, Chongqing Medical University
RESEARCH INTERESTS
Focused on the study of stem cell biology, bone development, and regenerative medicine for more than 20 years. Published 33 orthopedic research papers as first or corresponding author in Nat Med, Bioact Mater, Dev Cell, PNAS etc. with total IF>310 and citations >3000. His research team consists of 7 permanent members and 20 doctoral and master's students.
Obtained three projects of National Natural Science Foundation of China including a key joint project (Guangdong) and two key projects of Chongqing Science and Technology Bureau. His previous work on osteocytic Wnt signaling was selected as the outstanding research in the annual meeting by American Society for Bone and Mineral Research (ASBMR) in 2013, and was consecutively commented by Nature Reviews magazines. His research on Wnt and Notch signaling in orthopedics is at the forefront of the world.
Carries out translational study. He discovered the osteogenic microenvironments and established their 3D bioprinting system for integrative printing of hard materials and cells to reconstruct a bone development module with these microenvironments for bone regenerative repair. These microenvironments include functional cells and their decellularized matrix, secreted exosomes, microenvironmental factors, and small molecular drugs.
In addition, conducts research on the aging, degeneration, and regenerative rehabilitation of the sports system.
Research directions:
1. Molecular mechanisms on bone development and homeostasis
1) Basis and countermeasures for the prevention and treatment of bone fracture delayed union and nonunion
2) Basis and countermeasures for the prevention and treatment of bone loss caused by weightlessness
3) Bone degenerative disease and ferroptosis
2. 3D bioprinting and organoid bone construction
3. Development of bio-ink and biodegradable bone repair materials
4. Orientated differentiation, lineage specification, and spatial and temporal regulation of osteogenesis of stem cells/iPSC cells
5. Osteogenic drugs
6. Bone and aging
7. Skeletal biomechanics
HONOUR & AWARDS
2023.06 Top 10 Achievement Transformation Award in The First Chongqing Excellent Engineer Competition
2022.08 Winner Award of the First National Postdoctoral Innovation and Entrepreneurship Competition
2018.06 Leading Expert of Chongqing Chief Expert Workshop
2018.06 Expert of Chongqing Overseas Chinese Federation
2018.06 The Second Prize of the Chinese Overseas Chinese Contribution Award
2018.07 First Prize of Chongqing Scientific and Technological Achievement.
PUBLICATIONS
a) Xiaofang Wang#, Yufei Ma#, Jie Chen#, Yujiao Liu#, Guangliang Liu, Pengtao Wang, Bo Wang, Taketo Mark Makoto, Bellido Teresita, Xiaolin Tu*, A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis. Bioactive Materials 2022, 21:110-128. IF:18.9.
b) Yangxi Liu#, Xiaojie Ruan#, Jun Li#, Bo Wang, Jie Chen, Xiaofang Wang, Pengtao Wang and Xiaolin Tu*. The osteocyte stimulated by Wnt agonist SKL2001 is a safe osteogenic niche improving bioactivities in a polycaprolactone and cell integrated 3d module. Cells 2022, 11(5): 831-51. IF：6.0.
c) Pengtao Wang#, Xiaofang Wang#, Bo Wang#, Xian Li#, Zhengsong Xie, Jie Chen, Tasuku Honjo, Xiaolin Tu*. 3D printing of osteocytic Dll4 integrated with PCL for cell fate determination towards osteoblasts in vitro. Bio-Design and Manufacturing 2022, 5(3): 487-511. IF: 7.9.
d) Cen Luo#, Wenjuan Xu#, Xun Tang#, Xinyu Liu, Yu Cheng, Yixun Wu, Zhengsong Xie, Xiaohong Wu, Xin He, Qian Wang, Yao Xiao, Xueting Qiu, Zhurong Tang, Gaohai Shao, Xiaolin Tu*. Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation. Free Radical Biology and Medicine 2022, 188:337-350. IF:7.4
e) Bo Wang#, Saima Khan#, Pengtao Wang#, Xiaofang Wang, Yangxi Liu, Jingjing Chen, Xiaolin Tu*. A highly selective gsk-3β inhibitor chir99021 promotes osteogenesis by activating canonical and autophagy-mediated wnt signaling. Frontiers in Endocrinology 2022, 13: 926622. IF: 5.2.
f) Xiaolin Tu#,*, Jesus Delgado-Calle#, Keith W Condon, Marta Maycas , Huajia Zhang , Nadia Carlesso , Makoto M Taketo , David B Burr , Lilian I Plotkin , Teresita Bellido*. Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone. Proc Natl Acad Sci USA 2015,112(5): E478-86. IF：11.1.
g) Matthew J Hilton#, Xiaolin Tu#, Ximei Wu, Shuting Bai, Haibo Zhao, Tatsuya Kobayashi, Henry M Kronenberg, Steven L Teitelbaum, F Patrick Ross, Raphael Kopan, Fanxin Long*. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nature Medicine 2008, 14:306-14. IF: 82.9.
